3.step three. Exposure Items

Compared with men with BMI? 25 kg/m 2 , the age-adjusted risk of osteoporosis was over four-fold higher in those with BMI < 25 (odds ratio (OR) 4.4 (1.51, ) in age-adjusted model (Table 3). The association between BMI and osteopenia was similar among overweight/obese and normal weight men, although not statistically significant (Table 3).

Both Bmi and you will weight was coordinated having BMD, and you will BMC evidence as well as the most powerful Pearson’s relationship coefficients had been discover anywhere between lbs and https://datingranking.net/escort-directory/ you can BMC as a whole stylish and you may trochanter countries and you will the latest weakest of them was indeed ranging from Bmi and femoral neck BMC. The fresh correlations between decades and BMD and you will BMC evidence had been negative (Dining table 4).

This-adjusted proportion out-of BMD and you may BMC variation told me by the Body mass index and pounds try shown when you look at the Dining table 5. Lbs had a tendency to reveal greater variations in BMD and you will BMC delivery at all the examined skeletal web sites versus Bmi. It was shown by the steeper hill (?) of one’s particular linear regression traces. The greatest difference between BMD and you will BMC shipments appeared within trochanter BMC followed closely by lumbar BMC to possess lbs. Weight is a vital predictor away from BMD and you may BMC type for the old Iranian males.

cuatro. Conversation

In this study, both BMI and weight were associated with BMD, and obesity significantly decreased the risk for osteoporosis in men. These results are consistent with most previous studies, particularly in postmenopausal women, which indicated that lower BMI and weight were associated with lower BMD. Prospective studies found that the early postmenopausal women who have low BMI lose more bones compared to those with higher BMI tertiles [4, 8]. In other cross-sectional studies, however, thinness is related to both osteoporosis and increased fracture risk [10, 11]. Iqbal et al. found that low BMI is a good indicator for referral of women less than 60 years old for measurements of BMD. Similar studies also reported a consistent finding that lower BMI was associated with lower BMD [5, 6, 28]. In a study similar to ours, those with lower BMI were at higher risk of low BMD . The Studies of National Osteoporosis Foundation and others suggested that low BMI should be included in the risk assessment tools for evaluation of osteoporosis and osteoporotic fracture risk [29–31]. We found that men with BMI < 25 had 4.4 (95% CI 1.5, 12.8) times higher age-adjusted risk of osteoporosis than men with BMI ? 25. In contrast, Steinschneider et al. in a cross-sectional study reported that the correlation between BMD at the femoral neck and BMI was highly positive among postmenopausal women. A hospital-based study conducted in elderly men reported that overweight and obese men were more likely to have osteoporosis and osteopenia . The possible explanation for the discrepancies between these results might be related to populations, research designs, sampling methods, and methodological differences.

The new elements in which fat exerts positive effects to the BMD updates commonly totally clear. Brand new putative apparatus value away from fatty tissue to possess skeletal integrity probably stays in this new part of several adipokines in bones restorations compliment of impact on each other formation and you can resorption. Has just, limbs has been sensed an hormonal organ affecting weight handle and you may glucose homoeostasis through the steps out-of bone-derived products eg osteocalcin and you will osteopontin [23, 34–36]. The fresh new putative crosstalk between weight while the bones constitutes a homoeostatic opinions program where adipokines and you may particles produced by osteoblasts and you will osteoclasts portray the link out-of a working bone-adipose axis [34–36]. Obesity is additionally for the BMD by the sales out-of androgen so you’re able to estrogen , and therefore improves limbs mass in both folk [38, 39] and keeps fit plasma levels of insulin and managing factors including insulin-like progress foundation-step 1, leptin, and adiponectin . Simultaneously, being obese provides cushioning into cool in case there is a beneficial slip . Yet not, brand new components which most of these occurrences are present are unclear.

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